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Diabetes and heart ...
Diabetes and heart failure associations in women and men : Results from the MORGAM consortium
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- Chadalavada, Sucharitha (author)
- William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom
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- Reinikainen, Jaakko (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
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- Andersson, Jonas, 1977- (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Di Castelnuovo, Augusto (author)
- Mediterranea Cardiocentro, Naples, Italy
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- Iacoviello, Licia (author)
- Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine—EPIMED, Department of Medicine and Surgery, University of Insubria, Varese, Italy
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- Jousilahti, Pekka (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
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- Kårhus, Line Lund (author)
- Center for Clinical Research and Prevention, Copenhagen University Hospital—Bispebjerg and Frederiksberg, Copenhagen, Denmark
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- Linneberg, Allan (author)
- Center for Clinical Research and Prevention, Copenhagen University Hospital—Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Söderberg, Stefan (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Tunstall-Pedoe, Hugh (author)
- Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, United Kingdom
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- Lekadir, Karim (author)
- Artificial Intelligence in Medicine Lab (BCN-AIM), Departament de Matemàtiques and Informàtica, Universitat de Barcelona, Barcelona, Spain
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- Aung, Nay (author)
- William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom
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- Jensen, Magnus T. (author)
- William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, Herlev, Denmark
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- Kuulasmaa, Kari (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland
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- Niiranen, Teemu J. (author)
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Department of Internal Medicine, University of Turku and Turku University Hospital, Turku, Finland
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- Petersen, Steffen E. (author)
- William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, United Kingdom; Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, West Smithfield, London, United Kingdom; Health Data Research UK, London, United Kingdom; National Institute for Health and Care Research, London, United Kingdom
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Frontiers in Cardiovascular Medicine. - 2297-055X. ; 10
- Related links:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Background: Diabetes and its cardiovascular complications are a growing concern worldwide. Recently, some studies have demonstrated that relative risk of heart failure (HF) is higher in women with type 1 diabetes (T1DM) than in men. This study aims to validate these findings in cohorts representing five countries across Europe.Methods: This study includes 88,559 (51.8% women) participants, 3,281 (46.3% women) of whom had diabetes at baseline. Survival analysis was performed with the outcomes of interest being death and HF with a follow-up time of 12 years. Sub-group analysis according to sex and type of diabetes was also performed for the HF outcome.Results: 6,460 deaths were recorded, of which 567 were amongst those with diabetes. Additionally, HF was diagnosed in 2,772 individuals (446 with diabetes). A multivariable Cox proportional hazard analysis showed that there was an increased risk of death and HF (hazard ratio (HR) of 1.73 [1.58–1.89] and 2.12 [1.91–2.36], respectively) when comparing those with diabetes and those without. The HR for HF was 6.72 [2.75–16.41] for women with T1DM vs. 5.80 [2.72–12.37] for men with T1DM, but the interaction term for sex differences was insignificant (p for interaction 0.45). There was no significant difference in the relative risk of HF between men and women when both types of diabetes were combined (HR 2.22 [1.93–2.54] vs. 1.99 [1.67–2.38] respectively, p for interaction 0.80).Conclusion: Diabetes is associated with increased risks of death and heart failure, and there was no difference in relative risk according to sex.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- diabetes
- epidemiology
- heart failure
- MORGAM
- sex differences
Publication and Content Type
- ref (subject category)
- art (subject category)
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Chadalavada, Suc ...
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Reinikainen, Jaa ...
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Andersson, Jonas ...
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Di Castelnuovo, ...
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Iacoviello, Lici ...
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Jousilahti, Pekk ...
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Kårhus, Line Lun ...
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Linneberg, Allan
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Söderberg, Stefa ...
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Tunstall-Pedoe, ...
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Lekadir, Karim
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Aung, Nay
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Jensen, Magnus T ...
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Kuulasmaa, Kari
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Niiranen, Teemu ...
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Petersen, Steffe ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Frontiers in Car ...
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Umeå University